I think the major advances in particularly have been recognition for the pH negative group of patients, the incredible genetic diversity of this subgroup.Īdvances in the lab from colleagues who do molecular genetics research have really begun to define a lot more subtypes of this group, and for many of these subgroups, the genetic basis of the ALL can help identify particular treatment approaches, whether that's a targeted agent or information that predicts prognosis that may allow the treatment to be escalated or deescalated. So ALL, or acute lymphoblastic leukemia is, you know, historically been thought of as a disease with major subtypes, including B-cell and T-cell ALL, and then the so-called Philadelphia chromosome positive and Philadelphia chromosome negative ALL. Please notify if there are concerns regarding accuracy of the transcription. Editor’s note: This is an automatically generated transcript.
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